Objective Research and analysis the effect of elderly patients prophylactic use nimodipine on postoperative cognitive dysfunction during the perioperative period. Methods 80 cases of elderly patients ranging in age from 65~80 years old with non cardiac surgery under general anesthesia from January 2013 to January 2014. ASA Ⅰ ~ Ⅲ . 80 cases divided into two groups randomly, observational group (nimodipine group) and control group. Each group includes 40 cases. In observational group, nimodipine was injected by micro-pump after general anesthesia induction and maintained until the end of operation. In control group, NS was injected with the same dose. Two group of patients are tested with MMSE (simple intelligence scale for mental state examination) in pre-operation 1 day, after operation 1day, 2days, 4days, 7days. Results Compare with pre-operation 1 day and after operation 1 day, an apparent decline shows in the MMSE scores of two group of patients (P<0.05). After operation 1day and 2days, the MMSE scores of observational group declined less than control group (P<0.05). The chance of cognitive dysfunction in observational group was obviously lower than the control group after operation 1 day, 2 days, 4 days (P<0.05). Conclusion Nimodipine that uses during the general anesthesia surgery has positive effect to the occurrence of elderly cognitive dysfunction.%目的：研究与分析围术期预防性应用尼莫地平对老年患者全麻后认知功能障碍的影响。方法选取我院2013年1月～2014年1月，65～80岁非心脏全麻手术的老年患者80例，ASAⅠ~Ⅲ级，随机分为两组，观察组（尼莫地平组）和对照组，每组40例，观察组于全麻诱导后术中泵注尼莫地平，对照组泵注相同剂量的生理盐水，对两组患者手术前1 d，术后1 d、2 d、4 d、7 d进行MMSE量表（简易智能精神状态检查量表）评分。结果两组患者术后第1 d，MMSE评分均比术前1 d下降（P＜0.05），观察组患者术后1 d、2 d的MMSE评分下降低于对照组（P＜0.05），观察组患者术后1 d、2 d、4 d发生认知功能障碍的机率低于对照组（P＜0.05）。结论老年患者全麻术中应用尼莫地平对预防认知功能障碍的发生有积极作用。
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