大剂量地塞米松联合rhTPO治疗初治重症原发免疫性血小板减少症疗效观察

摘要

Objective To investigate the clinic effect of high-dose dexamethasone and rhTPO on initial treatment severe ITP.Methods 40 cases with ITP in our hospital from January 2014 to July 2016 were selected and divided into control group and observation group, 20 cases in each group. They were all given dexamethasone and observation group was added with rhTPO. Observe the effect and adverse reactions of the two groups.Results Total efficiency of observation group (75%) was higher than control group (30%), the difference was statistically signiifcant (P<0.05), adverse reaction rate of observation group (15%) was lower than control group (20%), the difference was not statistically signiifcant (P>0.05). ConclusionHigh-dose dexamethasone and rhTPO has signiifcant effect on initial treatment severe ITP, adverse reactions is less during treatment.%目的观察大剂量地塞米松结合rhTPO治疗初治原发免疫性血小板减少症（ITP）的疗效。方法选取我院2014年1月～2016年7月收治的初治重症ITP患者40例，随机分为两组，对照组及观察组，各20例，两组患者均给予地塞米松，观察组在此基础上加用rhTPO。观察两组患者疗效及不良反应发生情况。结果观察组治疗总有效率（75%）高于对照组（30%），差异有统计学意义（P＜0.05）；观察组不良反应总发生率（15%）低于对照组（20%），差异无统计学意义（P＞0.05）。结论 rhTPO结合大剂量地塞米松治疗初治ITP临床疗效好，且患者治疗过程中不良反应发生情况少。