异丙酚联合盐酸戊乙奎醚在无痛人流中的麻醉效果观察

摘要

目的：探讨异丙酚联合盐酸戊乙奎醚（长托宁）在无痛人流中的麻醉效果。方法选取2014年1月~2015年12月的80例需人流患者随机分为观察组与对照组，每组40例。观察组在静脉推注长托宁0.5 mg后1 min静脉注入异丙酚，再行人流手术；对照组仅给予静脉注入异丙酚后行人流手术，观察对比两组患者麻醉起效和苏醒时间、平均呼吸暂停时间、口腔分泌和呛咳反应情况、宫颈口松驰程度和心率的变化。结果观察组用药后平均呼吸暂停时间为（7.9±2.6）s；口腔分泌量（4.1±1.6）ml；出现呛咳反应0例；宫颈口松驰27例；用药前心率（73.2±6.4）次/分，用药后10 min心率（71.5±5.2）次/分，差异无统计学意义（t=1.3038，P＞0.05）；麻醉起效时间（3.5±0.8）min，苏醒时间（5.5±1.2）min。对照组用药后平均呼吸暂停时间为（37.1±4.3）s；口腔分泌量（12.4±2.3）ml；出现呛咳反应10例；宫颈口松驰5例；用药前心率（73.7±5.7）次/分，用药后10 min心率（66.2±6.1）次/分，差异有统计学意义（t=5.6817，P＜0.05）；麻醉起效时间（5.1±0.7） min，苏醒时间（6.5±1.4）min。上述观察指标组间对比，均存在统计学差异（P＜0.05）。结论异丙酚联合长托宁用于无痛人流能减少呼吸暂停时间，抑制口腔分泌，减少呛咳反应，改善宫颈口松驰度，抑制心率波动，提高无痛人流手术安全性，增强手术效果。%Objective To investigate the anesthetic effect of propofol combined with long length of anesthesia in painless induced abortion. Methods 80 cases of patients with January 2014 to December 2015 were randomly divided into observation group and control group, 40 cases in each group. In the observation group with intravenous injection of penehyclidine hydrochloride 0.5 mg 1 min after intravenous injection of propofol, the stream of people surgery again. The control group was given intravenous injection of propofol after abortion were compared between the two groups of patients the onset and recovery time, apnea time, changes of oral secretion and cough, cervix relaxation degree and heart rate. ResultsThe observation group after treatment, the average apnea time was (7.9±2.6) s, oral secretion (4.1±1.6) ml; choking reaction in 0 cases, 27 cases of cervix relaxation before treatment, heart rate (73.2±6.4) times/min, 10 min after using heart rate (71.5±5.2) times/min, difference no statistical signiifcance (t=1.303 8,P>0.05). The onset time of anesthesia (3.5±0.8) min, recovery time (5.5±1.2) min. The control group mean apnea time (37.1±4.3) s, oral secretion (12.4±2.3) ml; choking reaction in 10 cases; 5 cases of cervix relaxation before treatment; heart rate (73.7±5.7) times/min, 10 min after using heart rate (66.2±6.1) times/min, difference there was statistical significance (t=5.681 7,P<0.05). The onset time of anesthesia (5.1±0.7) min, recovery time (6.5±1.4) min. There were signiifcant differences in the observed indexes (P<0.05).Conclusion Propofol combined with penehyclidine hydrochloride for painless induced abortion can reduce the time of apnea, inhibit oral secretion, reduce cough, improve the cervix relaxation degree of inhibition of heart rate lfuctuations, improve the operation safety of painless, enhance the effect of surgery.