饱和水溶液法制备莫能菌素-β-环糊精包合物的研究

摘要

To study the preparation technology of inclusion compound carrying monensin,monen-sin was encapsulated withβ-cyclodextrin using saturated water solution.The phase identification of inclusion compound was examed by infra-red spectrum (IR ).Based on a comprehensive evaluation of inclusion efficiency,the optimal formulation and process conditions of inclusion compound carrying monensin were determined by orthogonal design methods.IR result showed that inclusion compound carrying monensin was formed;The best optimum of the preparation technology were as follows:The proportion of the quality of β-cyclodextrin and monensin was 3∶1,the temperature of inclusion was 40 ℃,and the time of inclusion was 1.5 h.The inclusion rate was 57.54%.This preparation technology was feasible,and enlarged the use of monensin. The study laid a foundation for improvement about dosage form of monensin.%为研究莫能菌素包合物的制备工艺，以β-环糊精为包合材料，采用饱和水溶液法制备莫能菌素β-环糊精包合物。用红外光谱法（IR）对包合物进行物相鉴定。以包合率为指标，运用正交设计法，确定最佳处方和工艺条件。IR 结果表明，药物与环糊精形成了包合物。当投料比为3∶1，包合温度为40℃，搅拌时间1．5 h 时，该制备工艺最佳，包合率为57．54％。该制备工艺可行，扩大了莫能菌素的应用，为莫能菌素的剂型改进奠定了基础。