不同工艺制备替米考星固体分散体及溶出特性研究

摘要

Different preparation of Tilmicosin solid dispersion and study its dissolution characteristics. By using single factor test choose carrier and drug carrier ratio, optimized by orthogonal design of tilmicosin solid dispersion preparation process, taking the drug dissolution rate as the study index, stirring speed, stirring time, curing time as influencing factors, each factor takes three levels, and determination of Tilmicosin content by HPLC method. The results show that, by melting method, with Poloxamer 188 as the carrier, drug carrier ratio is 1:3, medium speed for 45 min, curing for 12 h, the optimized process is stable and feasible, has better dissolution effect.%不同工艺制备替米考星固体分散体并研究其溶出特性。通过单因素考察选择载体与药载比后，采用正交设计优选替米考星固体分散体制备工艺，以药物溶出率为考察指标，搅拌速度、搅拌时间、固化时间作为影响因素，每个因素取3个水平，并利用HPLC法测定替米考星含量。结果表明，采用熔融法，以Poloxamer l88为载体，药载比为1∶3，中速搅拌45 min，固化12 h，优化得到的工艺稳定可行，溶出效果较好。