葡聚糖基水凝胶的制备及其应用的研究进展

摘要

葡聚糖是一种生物性多糖,主链上含有很多游离的羟基,易于修饰和交联. 葡聚糖水凝胶具有良好的溶胀性、生物相容性、生物可降解性,在物质分离、药物缓释和组织工程等领域具有较好的应用前景. 论文综述了近年来葡聚糖水凝胶的几种常见的制备方法,即反复冷冻-解冻法、化学交联法、接枝改性法、自由基聚合法,并对其在分离吸附、药物缓释、组织工程、医用材料等方面的应用研究进行综述,同时对其未来发展进行了展望.%As a kind of biological polysaccharide, dextran contains many free hydroxyl groups on the main chain, which is convenient for modification and crosslinking. The hydrogels prepared by dextran exhibited excellent swelling property, biocompatibility and biodegradability. Dextran is widely applied in the fields of substance separation, drug delivery and tissue engineering. Kinds of common preparation methods of dextran-based hydrogels, including repeated freezing-thawing method, chemical crosslinking method,grafting modification method,and free radical polymerization,have been summarized,Besides,the applications of dextran-based hydrogels in recent years are reviewed and the future developments are discussed in present study.