Glucose, as the template compound, was modified by glycidyl methacrylate and copolymerized with acrylic acid and acrylamide. After freeze drying, the pH-sensitive glulose-based hydrogels were obtained. The experimental conditions were studied and the optimal conditions were the 1∶4∶4 mass ratio of glucose/acrylic acid/acrylic amide, the 0. 5% dosage of cross-linking agent, initiator and reaction temperature at 65 ℃. And the swelling ratio of hydrogel obtained under these conditions was about 90. 5 g/g. Additionally, it was found that the swelling ratio of the glulose-based hydrogel increased with time extension and finally approached equilibrium in certain pH medium. And the swelling ratio of the hydrogels in the intestinal fluid without enzymes (pH=7. 4) was significantly higher than that in the gastric fluid without enzymes (pH=1. 2). Moreover, the hydrogels could keep basically no degradation in the two kinds of medium. This showed certain application prospect in tissue engineering materials.%以葡萄糖为模板化合物,利用甲基丙烯酸缩水甘油醚对其改性后与丙烯酸、丙烯酰胺进行共聚反应,再经冷冻干燥,制备了具有pH值敏感特性的葡聚糖基水凝胶,并表征了其结构,优化了制备条件。结果表明：最佳条件为葡萄糖/丙烯酸/丙烯酰胺质量比为1∶4∶4,交联剂用量0.5%,引发剂用量1%,反应温度为65℃,在此条件下,水凝胶的平衡溶胀度可达90.5 g/g。研究发现该葡聚糖基水凝胶在同一pH值介质中的溶胀度随时间延长而增大,最后趋于平衡；其在无酶人工肠液(pH值7.4)中的溶胀度明显高于无酶人工胃液(pH值1．2),且该凝胶在两种介质中基本无降解。
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