CBS催化合成R-3-奎宁醇

摘要

The chiral synthesis technique was applied to prepare R-3-quinine alcohol by catalytic reduction of 3-quinine ketone with the help of CBS catalyst. The yield and ee value were above 92% and 98% .respectively. The proposed synthesis method appeared to be convenient, high-yield, and applicable for industrial purpose.%探讨R-3-奎宁醇的合成工艺.通过手性合成的方法,以3-奎宁酮盐酸盐为原料,经CBS催化剂催化还原得R-3-奎宁醇.收率可达到92％以上,ee值可达98％以上.该合成路线操作步骤简单、收率高,具有工业应用价值.