吲哚醌类Schiff碱及其配合物的合成与抗肿瘤活性研究

摘要

合成了两种吲哚醌类Schiff碱配体及其过渡金属Cu(Ⅱ)、Zn(Ⅱ)、Mn(Ⅱ)、Co(Ⅱ)、Ni(Ⅱ)的配合物,并用电子光谱、红外光谱、1H NMR加以表征.采用MTT比色法测定了配合物的体外抗肿瘤活性.经电子光谱、红外光谱、1H NMR所研究的结构与所预测的基本一致,并获得了L1·Zn、L2·Cu、L2·Zn、L2·Mn、L2·Co、L2·Ni等配合物的体外抗肿瘤活性测试结果.L1·Zn配合物对肺癌细胞SPCA-1、舌癌细胞Tb、胃癌细胞MGC以及白血病细胞K562的抑制作用较弱,吲哚醌单Schiff碱配体及金属Zn均可能是导致L1·Zn配合物抗肿瘤活性较弱的因素.L2的配合物对癌细胞都有一定的杀伤作用,尤其是Cu(Ⅱ)的配合物,其对这几种细胞的抑制作用明显好于其他配合物.%Several schiff base ligands and their transition metal Cu(Ⅱ) >Zn(Ⅱ) >Mn(Ⅱ) .Co(Ⅱ) .Ni( Ⅱ)complexes were prepared and characterized by UV-Vis, IR and 'H NMR. Antitumor activities of the complexes in vitro were studied by the method of MTT. Structures studied by UV-Vis, IR and ' H NMR were basically in accordance with our prediction. Test results of L1 · Zn complex's antitumor activity in vitro had been acquired. Complex L1 · Zn showed a weak inhibition effect on tumor cells SPCA-1 ,Tb, MGC and K562, potentially because of indoledione single-Schiff base ligand and metal Zn. The complexes of L2 had antitumor activity. Among the five complexes,the Cu(Ⅱ)complex had the novel highest antitumor activity.