Hf(NMe2)4催化下芳香胺与丙烯酸叔丁酯的氮杂迈克加成反应

摘要

研究了以Hf(NMe2)4为催化剂的芳香胺与丙烯酸叔丁酯的氮杂迈克加成反应,讨论了催化反应过程中催化剂用量,反应温度,以及芳胺取代基对反应收事的影响.利用该方法合成了6种取代的氮杂加成产物,并对反应条件进行优化,使收率在18 ～63％之间.研究发现,芳香胺上取代基的给电子能力越强,反应收率越高,产物结构经1H NMR,13C NMR表征,证明为目标产物.%Hf(NMe2)4 were used as catalysts to study the aza-michael addition between arylamines with different electronic effect groups and tert-butyl acrylate. It is found that the aromatic amines can only react with one molecule of acrylate to generate secondary amines. Being catalyzed by Hf( NME2)4, in toluene,under 100 ℃,tert-butyl acrylate were reacted with six kinds of arylamines with different electronic effect substituent groups. We find that,the stronger the electron capacity of the substituent,the higher the yield of the reaction(from 18% to 63% ). The products were characterized by 1H NMR and 13C NMR,there were proved to be the target compounds.