L-丙氨酰-L-谷氨酰胺的合成反应研究

摘要

L-Alanyl-L-glutamine dipeptide(Ala-Gin) was prepared from L-ethyl lactate and L-Glutamine. First, 2-D-chloropropionyl chlorid was produted by chlorination,hydrolyzalion and acylation of L-ethyl lactate,then the title compond was prepared by condensation and ammoniation reaction of L-glutamine and 2-D-chloropropionyl chloride. The overallmolar yield was 43% based on L-ethyl lactate, the purity of Ala-Gin ( HPLC ) was more than 98%. The artical emphatically discussed synthesis of intermediate D-2-chloride propionic acid.%以L-乳酸乙醇和L-谷氨酰胺为原料,通过L-乳酸乙酯氯化、水解、酰化得到D-2-氯-丙酰基氯,再将D-2-氯-丙酰基氯与4-谷氨酰胺缩合后氨解,得到目标化合物,总收率43％,纯度(HPLC)大于98％.缩合反应的溶剂甲苯不需要脱水处理.重点讨论了中间体D-2-氯-丙酸的合成.