无溶剂“一锅法”催化合成氨甲酸酯基烷基萘酚衍生物

摘要

Carbamatoalkyl naphthols derivatives were synthesized efficiently by a one-pot three-component reaction of 2-naphthol, aldehydes and carbamates in the presence of cerous p-toluenesulfonate under solvent-free conditions. The effects of solvent condition, molar ratio of raw materials,amount of catalysts,and reaction temperature on the yields were investigated. The results of catalyst circulation showed that high catalytic activity remained after the catalyst was reused for three times. The structures of the products were determined and characterized by melting points,IR,1H NMR,13C NMR,MS technique and elemental analysis. Meanwhile,the probable mechanism for the reaction was proposed.%无溶剂条件下,对甲基苯磺酸亚铈可有效催化2-萘酚、醛和氨基甲酸酯三组分“一锅法”合成氨甲酸酯基烷基萘酚衍生物.考察了溶剂条件、原料配比、催化剂用量和反应温度对产率的影响.经催化剂循环研究,该催化剂重复使用3次仍保持较高活性.产物的结构通过熔点、IR、1H NMR、13C NMR、质谱和元素分析进行测定和结构表征.同时给出了该反应可能的反应机理.