噻唑类不对称双缩二氨基硫脲的合成及其抗菌活性研究

摘要

Fourteen novel bis thiosemicarbazone derivatives were obtained via condensation reaction of thiosemicarbazide with thia-zole-5-carboxaldehyde. The structures of the synthetic compounds were characterized by spectral data and elemental analysis. Anti-bacterial activity against Escherichia coli,Bacillus subtilis,Pseudomonas aeruginosa and Staphyloccocus aureus were tested. The re-sults indicated that three target compounds(3d,3f,3h)were particularly effective to inhibit Pseudomonas aeruginosa and Staphylo-coccus aureus.%噻唑-5-甲醛与氨基硫脲缩合反应，高产率的合成了14个未见文献报道的新型双缩二氨基硫脲类化合物，其结构经光谱和元素分析所表征。分别进行其对金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌、绿脓杆菌的抗菌活性测试。初步结果表明化合物3d，3f，3h对绿脓杆菌和金黄色葡萄球菌有很好的抑菌效果。