新型喹唑啉酮衍生物的合成

摘要

2,6-Dicyanoaniline derivatives (3 ) were synthesized from the multi-component condensation of aldehyde, malononitrile and ketone under the catalysis of ammonium acetate. Then 2 ,6-dicyanoaniline derivatives reacted with ketones to give mutli -substituted quinazolinone derivatives (5) using sodium hydroxide as catalyst at 100℃ or refluxing through intermolecule Pinner reaction via Dimroth rearrangement. The structures of the synthetic compounds were characterized by IR, 1H NMR, 13C NMR and MS. Quinazolinone derivatives are the important inter-mediate of a series of drugs.%以醛、丙二腈和酮为起始原料,在乙酸铵的催化下一锅合成了2,6-二氰基苯胺衍生物3,化合物3在NaOH催化下,与酮经过分子内Pinner反应到Dimroth重排组合转化,得到新型多取代喹唑啉酮衍生物5.化合物5的结构经IR,1H NMR,13C NMR和MS表征.喹唑啉酮衍生物是一系列药物的重要中间体.