METHOD FOR PRODUCING 3-(4-AMINOPHENYL)-6,7-DIFLUORO-1H-QUINAZOLINE-2,4-DIONE AND SALT THEREOF, METHOD FOR PRODUCING QUINAZOLINEDIONE DERIVATIVE USEFUL FOR THE PRODUCTION METHOD, AND IMINE DERIVATIVE USEFUL FOR THE METHOD FOR PRODUCING QUINAZOLINEDIONE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing a quinazolinedione derivative used as a medicine production intermediate, and to provide an imine derivative which is a production raw material for the quinazolinedione derivative.;SOLUTION: In the production method, 5,6-difluoro-3-(4-nitrophenyl imino)-1,3-dihidro-indol-2-one which is an imine derivative is reacted with an oxidizing agent such as peracetic acid, to thereby obtain a nitro group-containing quinazolinedione derivative. Further, in the production method, the nitro group-containing quinazolinedione derivative is reduced, to thereby obtain a quinazolinedione derivative represented by formula (3).;COPYRIGHT: (C)2012,JPO&INPIT