大蒜素/海藻酸钠/明胶/壳聚糖复合微球的制备及性能

摘要

Sodium alginate/gelatin/chitosan composite microspheres were prepared by complex coacervation method using allicin as model drug.The effects of different conditions of swelling,drug loading and sustained release of DSGCM were investigated.The results showed that,when gelatin and sodium alginate (mass ratio 1 ∶ 3) was 2％ and the allicin and the mix gel ratio was 1 ∶ 2,the preparation of DSGCM was spherical with particle sizes in the range of 0.8-0.9mm,and the drug loading and the entrapment efficiency were 24.3％ and 69.4％,respectively.The composite microspheres was sensitive to pH,and the swelling rate of DSGCM was 450％ in pH=7.4 media.The drug release process fitted well with the Higuchi equation kinetic model.The addition of gelatin could delay the drug release of DSGCM.%以大蒜素为模型药物,采用复凝聚法制备了海藻酸钠/明胶/壳聚糖复合微球,考察了不同条件对微球溶胀性、载药性能和缓释性能等指标的影响.结果表明,明胶和海藻酸钠(质量比为1∶3)为2％,大蒜素投入量与混合胶比为1∶2时,制备的载药微球(DSGCM)外形规则,粒径分布在0.8～0.9mm之间,载药量为24.3％,包封率为69.4％,复合微球具有pH敏感性,在pH=7.4介质中微球溶胀率达到450％,药物释放过程符合Higuchi方程,明胶的加入可以延缓DSGCM复合微球的药物释放性能.