B7-H6分子在恶性肿瘤中的研究进展

摘要

B7-H6分子是近年来发现的新型B7家族成员,可与自然杀伤(NK)细胞活化型受体NKp30特异性结合,介导NK细胞发挥肿瘤免疫杀伤作用.B7-H6在正常细胞表达中缺失,而在多种肿瘤细胞中表达上调.B7-H6分子的内在调控机制逐渐被揭示,B7-H6的靶向治疗在动物实验中获得了较好的效果,应用前景广阔.文章对B7-H6分子在恶性肿瘤中的最新进展进行综述.%B7-H6 has been discovered as a new member of the B7 family in recent years, it can specifically bind to the NKp30, an activated receptor of natural killer (NK) cells to mediate NK cells' tumor immunity killing effect. B7-H6 expression is upregulated in a wide variety of malignant tumor cells, but expression deficiency in normal tissue is detected. The intrinsic mechanism of B7-H6 regulation has been explored, and the treatment targeting B7-H6 has achieved a good effect in animal experiments, which shows a wide prospect of clinical application. This paper summarizes the latest progress of B7-H6 molecule in malignant tumors.