Molecular Diagnosis for Breast Malignancy

摘要

The overall project goal is to identify and evaluate new prognostic markers that can be used to indicate the metastatic potential of node-negative breast cancer. Cell surface antigens in the invading front; invadopodia, of cancer cells are considered as promising diagnostic indicators of metastatic potential. Five invasion-associated proteins are being examined in this project: seprase, dipeptidyl peptidase IV (DPPIV), membrane type matrix metalloprotease (MT-MMP), fibronectin, and extracellular matrix metalloprotease inducer (EMMPRIN).