小RNA病毒3C蛋白酶及其裂解底物

摘要

Picornavirus is a big family of animal viruses, viral protein synthesis needs its own proteases’cleavage to form sructural and functional proteins. 3C protease is one of picornaviruses’own proteases. 3C can also cleave some host proteins to benifit viral replication. 3C protease’s structural characteristics, active center, cleavage sites and cleavage substrates’functions are key of further understanding 3C protease mechanism. Here follows the review on these issues.%小RNA病毒科是一类大的动物病毒科，小RNA病毒蛋白的合成需要自身蛋白酶裂解形成多个结构蛋白和功能蛋白，3C蛋白酶是一些小RNA病毒的自身蛋白水解酶之一，3C蛋白酶还可以裂解一些宿主的蛋白，利于病毒的复制。3C蛋白酶结构特点、活性中心、酶切位点如何，裂解的底物功能怎样，是进一步了解3C蛋白酶作用机制的关键。就这些问题进行综述。