致病性弧菌外膜蛋白及其免疫原性研究进展

摘要

Vibrio is a common opportunistic pathogen in aquaculture environment, which can lead to an outbreak of mass mortality of fish and shellfish farming. Traditional chemical control methods because of drug resistance, drug residues and other issues make Vibriosis prevention face new challenges, and thus how to get safe and effective prevention and treatment of diseases caused by Vibrio becomes important and difficult. Vibrio is Gram-negative bacteria, the outer membrane is unique to the cell wall of this type of bacteria, which consist of protein, sugar and lipid. The outer membrane protein is easy to be recongnized as foreign by the host immune system then stimulate the humoral and cellular immunity, which may be used as an active ingredient of Vibrio vaccines. A review on the immunogenicity of pathogenic Vibrio outer membrane protein is to provide a new solution for the prevention and treatment of Vibriosis.%弧菌为水产养殖环境中常见的条件致病菌，其暴发可导致养殖鱼虾贝类大量死亡。由于常用的化学药物防治方法存在耐药性、药物残留等问题使得弧菌病的防治面临新的挑战，因而如何获得安全有效的防治方法成为弧菌所致疾病研究的重点和难点。弧菌为革兰氏阴性菌，外膜是该类型菌细胞壁特有的结构，由蛋白、糖和脂质构成。其中外膜蛋白易为宿主免疫系统识别为异物，可以激发机体的体液免疫和细胞免疫，有可能作为弧菌疫苗的有效成分。对弧菌外膜蛋白免疫原性的研究进展作一综述，以期为弧菌病的防治在外膜蛋白水平上提供一种有效的解决途径。