北冬虫夏草浸提液抗肿瘤细胞活性研究

摘要

Cordyceps sinensis contains cordycepin, cordyceps acid, polysaccharides, SOD and other various bioactive substances, it has a positive effect for the treatment of cancer. Based on this, through different weight gradient of Cordyceps sinensis extract, human cervical cancer cells (hela), human breast cancer cells (MCF - 7), human liver cancer cells (HepG2) growth experiments were carried out. The results showed that different concentrations of Cordyceps sinensis extract on tumor cell inhibition rate was different, and the inhibition rate increased with the extract of weight of Cordyceps sinensis increased; The optimal concentration of Cordyceps sinensis extract inhibited human cervical cancer cells (hela) was 0.3 g/mL, the optimal concentration of Cordyceps sinensis extract inhibited human breast cancer cells (MCF - 7) and human liver cancer cells (HepG2) was 0.4 g/mL. The data provides theoretical basis to improve the utilization rate of Cordyceps sinensis.%北冬虫夏草中含有虫草素、虫草酸、虫草多糖、SOD和氨基酸等多种生物活性物质，对癌症具有积极的治疗作用。基于此，对不同重量梯度北冬虫夏草浸提液，进行抗人宫颈癌细胞（hela）、人乳腺癌细胞（MCF-7）、人肝癌细胞（HepG2）生长试验，结果表明：不同浓度的北冬虫夏草水提液对肿瘤细胞抑制率不同，且随着水提液浓度的升高，抑制率随之升高；北冬虫夏草水提液抑制人宫颈癌细胞（hela）的最佳浓度为0.3g/mL，抑制人乳腺癌细胞（MCF-7）和人肝癌细胞（HepG2）的最适浓度为0.4g/mL。这一数据为提高北冬虫夏草的利用提供了理论依据。