树突状细胞在银屑病致病机制中作用的研究进展

摘要

Psoriasis is a chronic inflammation of skin caused by abnormal activation of T cells. Recent research shows that before the T cells are activated, the activation of Dendritic Cells (DCs) is the early-phase and pivotal process in the occurrence of psoriasis. Just because the quantity of DCs increase, their ability of stimulating T cells enhances and they secrete multiple cytokines which form the"cytokine storm" that leads to the erythema of psoriasis.%银屑病是多种因素造成的T细胞异常活化的慢性炎性反应皮肤病,最新研究表明,在T细胞被激活前,树突状细胞(DCs)的活化才是银屑病发生的起始和关键.正是因为DC数量增多、刺激T细胞能力增强、分泌多种细胞因子及化学增活素,形成“细胞因子风暴”,从而导致银屑病的红斑.