亲环素D及其介导的调节性细胞坏死

摘要

亲环素D(CypD)是亲环素家族中的一员,具有多种生物学功能.CypD位于线粒体基质上,为线粒体通透性转换孔(mPTP)的一个组成部分,进而调控mPTP的开放状态.mPTP开放会引起线粒体功能紊乱,进而诱发CypD途径依赖的细胞坏死,CypD可通过对mPTP的调控来参与调节性坏死.阐明CypD对mPTP的调控作用及其介导调节性坏死的机制,将为寻找防治心肌或脑缺血等损伤相关性疾病的药物提供新途径.%CyclophilinD ( CypD) , a member of cyclophilins family displays a variety of biological function .CypD lo-cates in the mitochondrial matrix .As an component of mitochondrial permeability transition pore ( mPTP ) , CypD plays an important role in the regulating of mPTP opening , which leads to mitochondrial dysfunction and CypD-de-pendent regulated necrosis .Elucidation of the mechanisms of CypD in regulating mPTP and the regulated necrosis will provide novel insights in injury-relevant diseases , such as cardiac or cerebral ischemia .