Method for treating an indication that results from an alpha 6 subunit containing integrin-mediated pathological condition in a mammal, to modulate the function of an integrin-containing alpha 6 subunit, to modulate an integrin-mediated response alpha 6 subunit, to modulate a response mediated and to identify an alpha 6 subunit containing integrin-mediated signal transduction pathway modifying agent, and cell surface and cell surface receptor complexes

摘要

"METHODS TO TREAT AN INDICATION RESULTING FROM AN ALPHA SUBUNIT 6 CONTAINING INTEGRINE-MEDIATED PATHOLOGICAL CONDITION, TO MODULATE THE FUNCTION OF AN ALPHA 6 SUBUNIT INCLUDING, TO MODULATE AN ALPHA SUBUNIT 6, CONTAINING AN INTEGRINE INTEGRINE-MEDIATED RESPONSE AND FOR IDENTIFYING AN ALPHA SUBUNIT 6 CONTAINING INTEGRINE-SIGNAL TRANSDUCTION PATH MODIFICATION AGENT, AND, CELL SURFACE AND SURFACE RECEIVER COMPLEX ". A method for modulating an alpha 6 subunit containing integrin-mediated signal transduction is described. The method involves contacting the cell with an effective integrin modulating amount of an alpha 6 subunit containing internally mediated signal transduction pathway modifying agent. Preferred agents are peptides having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.