1-脱氧野尻霉素晶体的制备及稳定性

摘要

Extracted 1-DNJ in mulberry leaves by oxalic acid solution(pH =5) ,HZ016,ZP-l ,ZN-1 chro-matographic techniques were used to purify 1 -DNJ, the purity exceeded 99%. Single crystal and powder crystal could get from saturated aqueous solution and ethanol solution. To inspect the stability of single crystal,powder crystal by accelerated experiment. Results showed that the related substance of crystalline powder is increase slightly,single crystal is stable. The first time use of water as a solvent system for the crystal of 1-DNJ. The stability of single crystal is the best.%采用pH=5的草酸溶液提取桑叶中的1-脱氧野尻霉素,离子交换树脂HZ016、ZP-1、ZN-1纯化,纯度为99％.采用饱和水溶液结晶和乙醇结晶,分别得到其单晶和粉末状晶体,进行加速实验,考察其稳定性.结果表明,粉末状晶体有关物质略有增加,单晶晶体基本无变化.首次使用水作为溶剂体系得到1-脱氧野尻霉素的单晶晶体,其稳定性最好.