萃取精馏分离2-甲基-1-丁醇与乙酸2-甲基-1-丁酯的过程模拟与工艺优化

摘要

猪胰脂肪酶催化外消旋2-甲基-1-丁醇酯交换反应,生成S-2-甲基-1-丁醇和乙酸2-甲基-1-丁酯,由于醇酯体系共沸,故采用间歇萃取精馏的方式,以N,N-二甲基甲酰胺作为萃取剂进行萃取精馏,优化了回流比、进料速率、进料温度等重要工艺参数,并应用过程模拟软件ChemCAD对2-甲基-1-丁醇和乙酸2-甲基-1-丁酯的萃取精馏工艺做全流程静态模拟.模拟结果与实验结果能较好吻合.%S-2-Methyl-1-butanol and 2-methyl-1-butyl ester were obtained by transesterification of racemic 2-methyl-1-butanol catalyzed by porcine pancreatic lipase. Due to the azeotropy of alcohol-ester system, DMF was used as the extractant in the batch extractive distillation of the products. Reflux ratio,rate and temperature of feed were optimized in the study. Static simulation of the whole process was simulated by ChemCAD for the extractive distillation of 2-methyl-1 -butanol and 2-methyl-1-butyl ester. Finally the experiment proved the simulation results were reliable.