以四氢呋喃、乙醇和水的混合溶液(体积比6∶1∶1)为分散剂,3-氨基丙基三乙氧基硅烷和苯基三乙氧基硅烷为功能单体,正硅酸乙酯为交联剂,氨水为催化剂,通过溶胶-凝胶法在二氧化硅微球表面制备了分子印迹聚合物.用分子对接的方法初步分析了链霉素与功能单体和交联剂之间的相互作用,验证了它们形成氢键的可能性.活化时间会影响分子印迹微球的形貌.吸附实验表明,分子印迹微球比非印迹聚合物微球对链霉素具有更优越的吸附性能和选择性.%A mixed solution of tetrahydrofuran, ethanol and water (volume ratio is 6: 1:1) was chosen as dispersion agent, 3-aminopropyltriethoxysilane and phenyltriethoxysilane as functional monomers, and tet-raethyl orthosilicate as cross-linker, while ammonia solution served as catalyst, the preparation of molecu-larly imprinted polymers on the surface of silica microspheres by sol-gel method. Preliminary analysis of the interaction between the streptomycin and functional monomer and crosslinker with the molecular docking, verifying the forming hydrogen bond possibility. The activation time will affect the morphology of the molecularly imprinted microspheres. The absorption capacity and selectivity of the obtained molecularly imprinted polymers (MIPs) were also evaluated for streptomycin and its analogue compounds in water samples.
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