Objective To investigate the drug sensitivity of nasopharyngeal carcinoma in vitro by ATP-TCA, and provide basis of neoadjuvant chemotherrap in nasopharyngeal carcinoma. Methods ATP-TCA was applied to determine the drug sensi-tivity of 84 nasopharyngeal carcinomas to eight common chemotherapeutics. Results The rate of evaluation of tissue samples was 100%. The drug with most sensitive efficiency was PXT (50%), followed by DDP (35.45%), 5-Fu (31.25%), NVB (23.53%), HCT (10.53%), MTX (10.53%), VP-16 (7.69%), THP (5.00%). The chemotherapy drugs showed strong individual difference in the killing effect on nasopharyngeal carcinoma. Conclusions The nasopharyngeal carcinoma tissues in vitro had significantly different sensitivity to eight kinds of chemotherapy drugs. ATP bioluminescence tumor drug sensitivity assay can be used in the clinical setting of individualized neoadjuvant chemotherapy for nasopharyngeal carcinoma (NPC) patients.%目的探讨肿瘤体外药敏实验 ATP 生物荧光法（ATP-TCA）在筛选鼻咽癌新辅助化疗药物中的应用。方法应用 ATP-TCA 法体外检测84例鼻咽癌活检组织对8种常用化疗药物的敏感性。结果组织标本的可评估率为100.0％。PXT 最敏感，体外有效率为50.00％，其次为 DDP （35.45％）、5-Fu （31.25％）、NVB（23.53％）、HCT （10.53％）、MTX（10.53％）、VP-16（7.69％）、THP（5.00％）。化疗药物对鼻咽癌的杀伤作用具有较强的个体差异性。结论体外鼻咽癌组织对8种化疗药物敏感性不同，存在明显差异性， ATP 生物荧光肿瘤体外药物敏感性检测法可用于临床制定个体化的鼻咽癌新辅助化疗方案。
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