中药添加剂对海南文昌鸡生长性能的影响及其安全性评价

摘要

[Objective] The aim was to study effects of traditional Chinese medicine additive（TCMA）on the growth performance of Hainan Wenchang chicken and to evaluate its safety to mouse. [Method] 180 female Wenchang chicken were randomly assigned to 5 groups with 3 replications each,each replication contain 12 chickens. Diets containing 0 and 600 mg/kg aureomycin as well as 0. 1%, 0.2% and 0.3% TCMA were fed to group 1 ,group 2,goup 3 ,group 4 and group 5 ,respectively. The test for growth lasted 6 weeks,among them body weight was measured per 7 days. Acute toxicity test and accumulation toxicity test were used to evaluate the safety of TCMA. [Result] Ultimate body weight in 0.2% TCMA was improved significantly （P〈0.05）. The median lethal dose （LD50）for mouse was more than 10 g/（kg-bw）, and the accumulation coefficient K was more than 5. [Conclusion] TCMA is a safe feed additive with high performance.%[目的]研究中药添加剂对海南文昌鸡生长性能的影响，并对其使用安全性进行评价。[方法]将180只雌性文昌鸡随机分为5组，每组3个重复，每重复12只。第1组为空白对照组，饲喂基础日粮；第2组为抗生素对照组．在基础日粮中添加600mg／kg的金霉素；第3,4、5组分别在基础日粮中添加0．1％、0．2％和013％的中药添加荆。生长试验共进行6周，每周称重。采用急性毒性试验、蓄积毒性试验对其安全性进行评价。[结果]0．2％中药添加剂能显著提高鸡的末体重（P〈0．05），中药添加剂的LDso〉10g／（kg·bw），蓄积系数K〉5。[结论]该中药添加剂为一种安全、有效的饲料添加剂。