急性有机磷农药中毒患者尿蛋白与尿肌酐比值的变化及意义

摘要

Aim To study the changes and clinical significance of UAlb/Ucr in patients with acute organophosphorus pesticide poisoning (AOPP). Methods 53 AOPP patients,including 16 mild poisoning group,22 moderate poisoning group and 15 severe poisoning group,and 40 healthy control group were selected to test and analyze the levels of cystatin C( Cys- C ),blood urea nitrogen ( BUN ),serum creatinine ( SCr ), as well as UAIb/Ucr. Results The UAIb/Ucr level in 53 AOPP patients were significantly higher than that in the control group. Conclusions The level of UAIb/Ucr could be used as an early indicator of glomerular and tubular damage in AOPP patients. It's more sensitive than blood BUN and SCr,and is important in diagnosis and treatment of early renal injury.%目的 研究急性有机磷农药中毒(AOPP)患者尿蛋白与尿肌酐比值变化及临床意义.方法 将53例AOPP患者依中毒程度分为三组,其中轻度16例、中度22例、重度15例,分别对血胱抑素C (Cys-C)、血尿素氮(BUN)、血肌酐(SCr)和尿蛋白定量及尿肌酐进行测定,并与40例对照组进行比较分析.结果 53例AOPP患者尿蛋白与尿肌酐比值均高于对照组.结论 尿蛋白与尿肌酐比值水平的变化可作为判断AOPP肾小球和肾小管早期受损的指标,较血BUN、SCr、敏感,对AOPP早期肾损伤诊断及治疗有重要意义.