350例头孢菌素类抗生素不良反应报告分析

摘要

Aim To analyze the characteristics and regularity of adverse drug reactions( ADRs )induced by cephalosporins. Methods A retrospective investigation was made into 350 cases of ADR of cephalosporins collected by the ADR Monitoring Center in the Third Peo ple' s Hospital from 2005 to 2009. Results 350 ADR cases involved 21 drugs of cephalosporins. Skin and its accessories damage ac counted for the highest percentage of ADR of cephalosporins. The drug which caused most ADR was cefoperazon. New and severe ADR were seen in 13 cases,accounting for 3.7％. Conclusion Great importance should be attached to ADR monitoring so as to reduce the incidence of ADR by cephalosporins%目的 了解该院头孢菌素类抗生素不良反应发生特点与一般规律,为临床合理用药提供参考.方法 采用回顾性调查方法对2005～2009年该院ADR监测中心收集到的350例头孢菌素类抗生素ADR报表进行统计分析.结果 350例ADR报表中涉及21种头孢菌素类抗生素,ADR累及皮肤及其附件损害最多,发生ADR头孢菌素类抗生素以头孢哌酮居多;新的和严重的ADR 13例,占3.7%.结论 临床使用头孢菌素类抗生素时应高度重视不良反应的监侧,减少ADR的发生.