目的 探讨经支气管针吸活检(TBNA)结合液基薄层细胞技术(TCT)对肺癌的诊断价值.方法 回顾性分析2011年4月-7月在无锡市第四人民医院气管镜室行经支气管针吸活检术确诊的肺癌45例,穿刺针常规穿刺抽吸细胞行涂片细胞学诊断,然后将TCT液冲洗穿刺针,冲洗液行TCT检查.对比涂片法、TCT法和涂片法结合TCT法诊断肺癌的敏感性.结果 45例肺癌患者中40例(40/45,89%)在涂片法中找到癌细胞;36例(36/45,80%)在TCT法中找到癌细胞;5例(5/45,11.1%)仅在TCT法中找到癌细胞;9例(9/45,20%)仅在涂片法中找到癌细胞;31例(31/45,68.9%)在涂片法和TCT法中均找到癌细胞.单纯涂片法找癌细胞、单纯TCT法找癌细胞和涂片法结合TCT法诊断肺癌敏感性经统计学计算P＜0.05,后者可明显提高诊断肺癌的敏感性.结论 经支气管针吸活检是一种诊断肺癌的安全有效的方法,常规细胞涂片结合液基薄层细胞学技术能提高诊断敏感性,值得临床推广应用.%Objective To assess the value of lung cancer diagnosed by combining Iransbronchial needle aspiralion wilh thinprep cytotogic lesl. Methods Forly-five lung cancers were analysed relrospeclively which were confirmed by Iransbronchial needle aspiralion al the Wuxi No. 4 Peoples' Hospilal bronchoscope room from April 2011 to July 2011. We smeard on plales and syringed needle by TCT liquid af ler undergoing TBNA. We sludied the diagnosis sensilivily of the ihree ways by means of only Iradilional way, only TCT and Iradilional way combining wilh TCT. Results In 45 cases, 40 cases(40/45, 89%) were found malignant cells by Iradilional way; 36 cases(38/45, 80% ) were found malignant cells by TCT; 5 cases(5/45, 11.1%) by only TCT; 9 cases(9/45, 20% ) by only Iradilional way; 31 cases(31/45, 68. 9%) were found malignant cells by bolh Iradilional way and TCT. Statistical analyses of the difference in the diagnostic yield among the three ways were performed. A P-value tower than 0. 05 was considered statistically significant. Combining traditional way with TCT could improve the sensitivity of diagnosis lung cancer. Conclusion TBNA is a safe and efficient technique which diagnoses the lung cancer. We can improve the sensitivity of diagnosing lung cancer by combining traditional way with TCT and it is worth generalizing in clinic.
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