PARP-1、P-gp和 LRP在肺腺癌中的表达和相关性研究

摘要

Objective To investigate the expression and correlation of PARP-1,P-gp and LRP in lung adenocarcinoma .Methods The expression of PARP-1,P-gp and LRP in 61 adenocarcinoma of lung tissues and 20 adjacent tissues was detected by immunohistochemi-cal SP method.Results The positive expression rate of PARP-1,P-gp and LRP in patients with lung cancer were 77.05%,50.82%and 67.21%respectively.The expression of PARP-1,P-gp and LRP in lung adenocarcinoma was significantly different from that in ad-jacent tissues(P<0.05).The expression of LRP was only closely correlated with lymph node metastasis (P<0.05).While the expres-sion of P-gp and PARP-1 was not correlated with the clinic pathological characteristics .LRP expression was positively correlated with PARP-1 and P-gp.There was no significant correlation between P-gp and PARP-1(r=0.223,P=0.084).Conclusion The drug re-sistance in lung cancer patients is affected by various factors .THE expression of PARP-1, P-gp and LRP have some correlation in lung adenocarcinoma .The expression of LRP was closely related to lymph node metastasis .%目的：探讨聚腺苷酸二磷酸核糖聚合酶-1（PARP-1）蛋白与P糖蛋白（P-gp）、肺耐药相关蛋白（LRP）在肺腺癌中的表达和相关性。方法采用免疫组化SP法检测61例肺腺癌组织和20例癌旁正常肺组织中PARP-1、P-gp和LRP的表达结果。结果 PARP-1、P-gp和LRP的阳性表达率分别为77．05％、50．82％、67．21％，与周围癌旁组织差异有显著性（P＜0．05）。 LRP的表达与肺腺癌淋巴结转移密切相关（P＜0．05），P-gp、PARP-1与临床病理特征无明显相关（P＞0．05）。 P-gp与LRP、PARP-1与LRP之间呈正相关（r分别为0．525、0．269，P＜0．05），P-gp与PARP-1之间无明显相关性（r＝0．223，P＝0．084）。结论P-gp、LRP和PARP-1在肺腺癌中的表达有一定的相关性，联合检测三者可作为判断肺腺癌恶性程度的生物学指标。