高尿酸血症治疗药物黄嘌呤氧化酶抑制剂的研究进展

摘要

Hyperuricemia is a metabolic disease resulting from multiple factors,and xanthine oxidase (XO) is an important target for hyperuricemia therapy.Due to the determination of crystal structure of the enzyme and application of CADD and HTS,there emerge a large number of xanthine oxidase inhibitors which have good activity for lowering uric acid in recent years.Using traditional Chinese medicine to treat hyperuricemia is prevalent in China.It is an important method to modificate natural product to find new compounds. In this article,we review the compounds which have excellent inhibitory activity of xanthine oxidase based on the pathological mechanism.%高尿酸血症是由多种原因引起的代谢性疾病，黄嘌呤氧化酶（XO）是药物治疗高尿酸血症的重要靶点。随着黄嘌呤氧化酶晶体结构的解析、计算机辅助药物设计和高通量筛选等技术的运用，近年涌现了许多具有良好的 XO 抑制活性的化合物。中药也是我国治疗高尿酸血症的一种主要方式，对天然化合物进行结构修饰也是寻找新化合物的重要方法。该文基于高尿酸血症的产生机制，对具有良好 XO 抑制活性化合物进行综述。