隆突性皮肤纤维肉瘤17例临床病理分析

摘要

目的 探讨隆突性皮肤纤维肉瘤(DFSP)的临床病理特征、诊断及鉴别诊断要点.方法 回顾性分析17例DFSP临床特征、病理组织学特点、免疫组化特点及治疗和预后.结果 17例DFSP中,男性13例,女性4例,平均年龄37.3岁.躯干部14例,头部2例,前臂1例.病变均位于真皮及皮下组织,瘤细胞呈特征性的席纹状或车辐状排列伴浸润性生长,免疫组化显示CD34和Vimentin弥散阳性,2例SMA灶区阳性,S-100均阴性.结论 DFSP是低度恶性软组织肿瘤,通过组织学及免疫组化可确诊,手术切除是主要的治疗方法.%Objective To explore the clinicopathologic characteristics ,diagnosis and differential diagnosis of dermatofibrosarcoma protu -berans (DFSP).Methods The clinical features,histopathological features,immunohistochemical features ,treatment and prognosis of 17 cases of DFSP were retrospectively analyzed .Results Among 17 cases of DFSP,13 cases were male and 4 cases were female with an average age of 37.3 years;there were 14 cases in the trunk,2 cases on head and 1 case in the forearm.DFSP lesions were located in the dermis and subcutaneous tissue ,and the tumor cells showed characteristic mat -like or car-like arrangement with invasive growth .Im-munohistochemistry showed that the expressions of CD 34 and Vimentin were diffusely positive,SMA focal areas of 2 cases were positive and S-100 was negative.Conclusions DFSP is a low grade malignant soft tissue tumor .It can be diagnosed by histology and immuno -histochemistry.Surgical resection is the main treatment method for DFSP .