血清 S100B蛋白和神经元特异性烯醇化酶在新生儿缺氧缺血性脑病早期诊断中的应用价值

摘要

目的：探讨血清 S100B蛋白和神经元特异性烯醇化酶（NSE）在新生儿缺氧缺血性脑病（HIE）早期诊断及判断预后的应用价值。方法选取2010年1月至2014年12月深圳市儿童医院新生儿科住院的 HIE的患儿和健康新生儿作为研究对象。健康对照组40例，HIE组97例，其中轻度组41例，中度组30例，重度组26例。入组的新生儿均于出生后的第1、3、7天晨起空腹时采集静脉血测定血清S100蛋白和 NSE 含量。结果 HIE 组患儿各个时间点 S100B 蛋白和 NSE 含量均明显高于健康对照组（P均＜0.05）。治疗前中、重度组血清 S100B蛋白和 NSE含量明显高于轻度组（P ＜0.05）经治疗后血清 S100B蛋白和 NSE含量均明显下降（P均＜0.05）。血清 S100B蛋白含量与 NSE含量呈正相关（P ＜0.05）。结论血清 S100B蛋白和 NSE在 HIE的早期诊断、损伤程度及预后的判断有重要意义。%Objective To evaluate the diagnosis of protein S100B and neurone specific enolase(NSE)in neonates with hypoxic-is-chemic encephalopathy(HIE). Methods The data of 137 neonates hospitalized in our hospital,including 40 healthy neonates,41 neonates with mild HIE,30 neonates with medium HIE and 26 neonates with severe HIE,from Jan. 2010 to Dec. 2014 were analyzed retrospectively. The levels of protein S100B and NSE were detected in all newborn infants on the 1d,3d and 7d after birth. Results Compared with healthy neonates group,protein S100B and NSE in HIE groups were significantly higher (P < 0. 05). The levels of protein S100B and NSE were all significantly decreased after treatment. The relationship between protein S100B and NSE in neonates with HIE was positively correlated. Conclusion Protein S100B and NSE are good biomarkers for the early identification of HIE,its extent of damage and the prognosis.