限进填料及其在生物样品分析中的应用

摘要

限进填料是一类特殊的萃取介质,允许生物基质直接、反复进样分析,实现待测物质的纯化和富集.限进填料萃取是生物分析领域的一种快速、简便、准确的在线样品制备方法.本文就限进填料的原理、种类及其在生物样品分析中的应用进行了综述.%The restricted-access materials (RAMs) are special extraction sorbents which allow direct and repetitive injection of complex bilogical matrices, enabling effective pre-concentration and clean-up of biological fluids for analysis. RAM extraction is a rapid, simple, accurate and on-line sample preparation technique.This article describes the principle and types of RAMs and gives a review of their applications in the analysis of biological samples.