血小板衍生生长因子信号途径在醛固酮致心肌纤维化中的作用及其可能的机制

摘要

The connection between aldosterone (ALD) and myocardial fibrosis has been established. However, the molecular signaling pathways for myocardial fibrosis induced by ALD remain unclear. Platelet-derived growth factors ( PDGFs) promote fibroblasts and smooth muscle cells to enter mitosis. It has been reported that a high expression of PDGFs may lead to myocardial fibrosis, which suggests that PDGF-PDGFR signaling pathways may be an important molecular mechanism in myocardial fibrosis induced by ALD. This article reviews new insights into the PDGF-PDGFR signaling pathways and the relationship between PDGF-PDGFR signaling pathways and myocardial fibrosis induced by ALD.%醛固酮可以导致心肌纤维化的观点已被大量研究证实,但目前醛固酮导致心肌纤维化的炎症分子机制尚不清楚.血小板衍生生长因子是一种可促进成纤维细胞及血管平滑肌细胞有丝分裂增殖并具有趋化作用的因子,血小板衍生生长因子的高表达导致心肌纤维化已被大量文献报道,提示血小板衍生生长因子信号途径可能为醛固酮致心肌纤维化重要后续分子机制之一.现就血小板衍生生长因子信号途径在醛固酮致心肌纤维化过程中的作用及可能的机制做一综述.