游泳运动和二甲双胍对肥胖大鼠chemerin蛋白表达水平的影响

摘要

Objective To observe the effects of swimming exercise, metformin and the combination of both inter-ventions on chemerin protein expression levels in epididymis adipose tissue ( EAT), subcutaneus adipose tissue ( SAT) and muscle tissue (MT) of obesity rats and to explore the relationship between chemerin and obesity-related metabolic disorders. Methods The 70 male conventional SD rats were divided into control diet group(n=10) and high fat group (n=60). After 16 weeks obesity model(n=40) was established and was randomly divided into four groups:high fat group(HF), swimming group(SWI), metformin group(MET), and the combination of swimming and metformin group(SAM) with 10 rats in each group. Chemerin protein expression levels in EAT, SAT and MT were determined by Western blot. Results ① After 22 weeks high fat diet induced obesity, chemerin protein ex-pression levels of obesity group in EAT, SAT and MT, especially that of EAT increased compared to NC group(P0.05)。结论①正常SD大鼠高脂饲养后可引起肥胖及脂肪和肌肉组织中chemerin蛋白表达增加；②游泳运动和二甲双胍及两者联合干预均可显著降低脂肪组织,尤其是内脏脂肪组织中chemerin蛋白的表达。