Objective To study whether the executive function is impaired in frontal lobe low-grade glioma ( LGG) patients and find related functional brain areas. To investigate the possible methods the executive function is im-paired and reconstructed. Methods Stroop color-word test (CWT) was applied in patients (n=15) and healthy controls (n=15) to investigate the executive function. Rest-state blood oxygenation level dependent functional MRI ( BOLD-fMRI) data were collected from the frontal lobe LGG patients and healthy controls. Regional homogeneity ( ReHo) approach was also applied for rest-state BOLD-fMRI data analysis and then calculated the different areas in two groups. Results In CWT, the accuracy and the average response time were significantly different between pa-tients and the healthy controls(P<0. 05). Patients showed increased and decreased brain regions in ReHo in the resting state compared with the controls. The increased ReHo was distributed over bilateral inferior temporal gyrus, bilateral middle temporal gyrus, right fusiform gyrus, right occipital gyrus. The decreased ReHo was found in right caudate, bilateral cingulated gyrus, left medial frontal gyrus, right post central gyrus. Conclusion The executive function is impaired by frontal LGG and BOLD-fMRI shows the regions related to executive function have been dis-rupted and suggests the compensated region may be temporal lobe.%目的：研究额叶低级别胶质瘤( LGG)患者的执行功能是否存在损害和相关的脑功能区域，探讨执行功能受损及代偿方式。方法收集15例额叶LGG患者(病例组)和15例正常者(对照组)的基本资料。应用 Stroop 色词测验( CWT)比较两组执行功能差异；再通过静息态血氧水平依赖功能磁共振成像( BOLD-fMRI)扫描，应用局部一致性( Re-Ho)方法处理BOLD-fMRI数据，得出病例组与对照组之间差异脑区。结果病例组与对照组在CWT中的正确率及平均反应时间差异有统计学意义( P<0．05)。病例组ReHo值比对照组升高的区域主要在：双侧颞下回、双侧颞中回、右侧梭状回、右侧枕中回；对照组ReHo值比病例组升高的区域主要在：右侧尾状核、双侧扣带回、左侧额叶内侧回、右侧中央后回。结论额叶LGG患者执行功能受损，与执行功能显著相关部位的神经元活动下降，并提示颞叶为可能的代偿部位。
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