血清转化生长因子β1、血管内皮生长因子在布－加综合征患者中的表达研究

摘要

Objective To study the expression of transforming growth factor-β1( TGF-β1) and vascular endothelial growth factor ( VEGF) in Budd-Chiari syndrome , and to explore whether serum TGF-β1 and VEGF play important roles in the progression of Budd-Chiari syndrome .Methods There were 101 cases of Budd-Chiari syndrome in the experimental group .During the same period , 125 controls were recruited from the medical examination center .The serum concentrations of TGF-β1 and VEGF were detected by ELISA .Results The serum concentrations of TGF-β1 and VEGF in the experimental group were higher than those in the control group ( P<0.001 ) .In the BCS group , the serum concentrations of TGF-β1 and VEGF were different significantly between pure BCS patients , BCS with stasis cirrhosis patients and BCS with hepatic carcinoma patients (P<0.001).Among them, the serum concentra-tions of the two factors of BCS with hepatic carcinoma patients were higher than BCS with stasis cirrhosis patients , and the latter was higher than the pure BCS patients ( P<0.05) .The serum TGF-β1 and VEGF were positive cor-related in the BCS group ( r=0.30 ,P=0.01 ) .Conclusion The serum concentrations of TGF-β1 and VEGF in-crease with the progression of BCS , and the synergistic effect between TGF-β1 and VEGF may accelerate the devel-opment of BCS .%目的：研究血清转化生长因子β1（ TGF-β1）、血管内皮生长因子（VEGF）在布－加综合征（BCS）患者中的表达，探讨其在BCS病情进展中的作用。方法选取101例BCS患者作为实验组，选取健康体检者125例作为对照组。采用ELISA法检测两组人群血清TGF-β1、VEGF表达水平。结果实验组血清TGF-β1、VEGF的含量高于对照组血清TGF-β1、VEGF的含量，差异均有统计学意义（ P＜0.001）。实验组中单纯BCS患者、BCS合并淤血性肝硬化患者、BCS合并肝癌患者血清TGF-β1、VEGF表达水平比较，差异均有统计学意义（P＜0.001），其中，BCS合并肝癌患者血清TGF-β1、VEGF水平高于BCS合并淤血性肝硬化患者，BCS合并淤血性肝硬化患者血清TGF-β1、VEGF水平高于单纯BCS患者，差异均有统计学意义（ P＜0.05）。 BCS患者血清TGF-β1与VEGF呈正相关性（ r＝0.30，P＝0.01）。结论随着BCS患者病情的进展，患者血清TGF-β1、VEGF表达水平增高，两因子的协同作用可能会加快病情的发展进程。