重症肌无力与CTLA-4基因多态性的Meta分析

摘要

目的 探讨细胞毒性T淋巴细胞相关抗原-4(CTLA-4)基因多位点单核苷酸多态性(SNP)与重症肌无力(MG)易感性的关联情况.方法 通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普、PubMed、Cochrane Library、OvidSP、Wiley Online Library、EBSCO、Elsevier Science Direct、Springer Link数据库检索CTLA-4基因与MG相关的病例对照研究,利用RevMan 5.3软件计算其基因型和等位基因与MG的关联性.结果 共纳入10篇文献,将MG分为胸腺瘤型MG(TAMG)、胸腺增生型MG(THMG)、自身免疫性MG(AIMG).Meta分析显示携有CTLA-4基因rs231775 G等位基因的人群罹患MG的风险增高(OR=1.55, 95% CI:1.13~2.12,P=0.006)、罹患AIMG的风险增高(OR=1.39, 95% CI:1.09~1.77,P=0.007),携有rs733618 CC基因型的人群罹患AIMG的风险增高(OR=3.28, 95% CI:1.89~5.70,P<0.001),携有rs733618 C等位基因的人群罹患AIMG的风险增高(OR=1.76, 95% CI:1.30~2.37,P<0.001).结论 CTLA-4基因rs231775 G等位基因、rs733618 CC基因型和C等位基因与AIMG易感性之间有关联性.%Objective To explore the association between CTLA-4 gene polymorphism and susceptibility to mysathenia gravis(MG).Methods The case-control studies from Chinese biomedical database, Chinese national knowl-edge infrastructure, Wanfang, Weipu, PubMed, Cochrane Library, OvidSP, Wiley Online Library, EBSCO, Elsevier Science Direct, Springer Link databases for the association CTLA-4 gene polymorphism with MG.The association strength were assessed by RevMan 5.3 software.Results Ten references were enrolled in total.MG was divided into thymoma-associated MG(TAMG), thymic hyperplasia MG(THMG) and autoimmune MG(AIMG).The Meta analysis showed that carriers of rs231775 allele G have higher risk of MG(OR=1.55, 95% CI:1.13~2.12,P=0.006), and higher risk of AIMG(OR=1.39, 95% CI:1.09~1.77,P=0.007) by subgroup analysis.Carriers of rs733618 genotype CC(OR=3.28,95% CI:1.89~5.70,P<0.001) and allele C(OR=1.76, 95% CI:1.30~2.37,P<0.001) have higher risk of AIMG by subgroup analysis.Conclusion The meta analysis reveales that rs231775 allele G, rs733618 genotype CC and allele C of CTLA-4 gene is associated with the susceptibility to MG.