对果糖嗪的合成方法进行了研究.选用2-氨基-2-脱氧葡萄糖胺盐酸盐和钠作原料,在甲醇中于70℃回流反应4h,反应产物经价格低廉的732型阳离子交换树脂柱层析和717型强碱性阴离子树脂中和及活性炭脱色,再经多次甲醇重结晶,得到纯度为95％以上的果糖嗪.该产品再通过高效液相制备色谱得到纯白色固体,其纯度可达98％以上,在4℃可保存至少2个月而不降低纯度.%Fructosazine was synthesized by refluxing 2-amino-2-deoxyglucose amine hydrochloride and sodium in metha-nol at 701 for 4 hours. The reaction products were purified with 732 type cation exchange resin column chromatogra-phy, neutralized with 717 strong basic anion exchange resin, decolorized with activated carbon, and crystallized in meth-anol to obtain fructosazine with 95% and above purity. The product was further purified by preparative high-performance liquid chromatography to obtain purer white solid with 98% and above purity, which might be stored within two months at 4℃, without degradation.
展开▼
