2型糖尿病鼠类模型的研究进展

摘要

Mouse and rat models of type 2 diabetes mellitus play a key role in basic and clinical translational stud-ies.Different animal models should match the determined investigational objects and methods .In this review, the estab-lishments and diabetes-specific changes of various animal models were described , which will be helpful for better use of ani-mal models in research of diabetes mellitus .%小鼠、大鼠糖尿病模型对基础与临床防治研究十分重要，不同的研究目标对应不同的动物模型载体。本文就目前常用的2型糖尿病鼠类模型的构建、主要疾病特征及应用等进行评述，为研究者了解、选择适合的动物模型提供参考。