狭叶荨麻提取物抗炎镇痛药理作用研究

摘要

目的：探讨狭叶荨麻提取物的抗炎镇痛药理作用。方法：观察狭叶荨麻提取物对二甲苯所致小鼠耳肿胀模型、对蛋清所致大鼠足肿胀模型、对醋酸所致小鼠扭体反应模型以及对小鼠热板镇痛模型实验的影响。结果：与模型组比较，狭叶荨麻乙酸乙酯提取物组能显著抑制二甲苯所致小鼠耳肿胀、蛋清所致大鼠足肿胀，并对醋酸所致小鼠扭体反应以及对热板小鼠表现出显著的镇痛作用。结论：狭叶荨麻乙酸乙酯提取物具有显著的抗炎镇痛作用。%Objective: To explore the effects of anti -inflammation and analgesia of extracts from Urtica angustifolia . Methods: Research of anti -inflammatory effect were done through dimethylbenzene -induced ear swelling models of mice, egg white -induced paw edema models of rats and research of analgesic effect were done through acetic acid -in-duced writhing reaction on mice and hot plate -induced pain on mice.Results: Above experiments showed that ethyl ac -etate extract group could significantly restrain dimethylbenzene -induced ear swelling of mice and egg white -induced paw edema of rats compare with model group .At the same time, ethyl acetate extract had a significantly analgesic effect on acetic acid -induced writhing reaction on mice and hot plate -induced pain on mice.Conclusion: This study demon-strates that ethyl acetate extract from Urtica angustifolia has a remarkably anti -inflammatory and analgesic effect .