家蚕细胞自噬和凋亡研究进展

摘要

家蚕变态发育由蜕皮激素(20E)和保幼激素(JH)协同调控,细胞自噬和细胞凋亡是昆虫蜕皮和变态期间的两个重要生理过程,两者相辅相成.20E通过调控一系列自噬和凋亡相关蛋白来诱导昆虫细胞自噬和凋亡.就家蚕细胞自噬和凋亡的研究进展作一综述,以便为其在家蚕变态发育过程中的重要作用奠定基础.%The development and metamorphosis of silkworm are coordinately regulated by molting hormone 20-hydroxyecdysone and juvenile hormone.Autophagy and apoptosis are the two main events during molting and metamorphosis,they are correlated with each other.20-hydroxyecdysone induces autophagy and apoptosis of in-sect cell by regulating a series of proteins related to autophagy and apoptosis.This paper summarizes the pro-gress in the research on autophagy and apoptosis of silkworm so as to establish a basis for revealing the impor-tant role of autophagy and apoptosis in the process of molting and metamorphosis.