目的：探讨二期梅毒患者体内苍白密螺旋体感染与细胞免疫功能之间的相互影响。方法：采用双抗体夹心ELISA法检测有皮损的二期梅毒组、治疗后两年内RPR阴转组及RPR未阴转组患者血清γ－干扰素（IFN－γ）水平，并对上述各组之间的IFN－γ水平进行对比分析。结果：有皮损的二期梅毒患者血清IFN－γ水平显著高于正常对照组和RPR阴转组，差异均具有显著统计学意义（P＜0．01）；RPR未阴转组血清IFN－γ水平明显低于正常对照组和RPR阴转组，差异均具有显著统计学意义（P＜0．01）。结论：有皮损的二期梅毒患者细胞免疫功能显著增强；治疗后RPR未阴转的二期梅毒患者体内存在细胞免疫功能抑制现象；二期梅毒治疗后RPR阴转的患者，其细胞免疫基本恢复到正常的状态。% Objective:To investigate the relationship between treponema pallidum infection and cellular immunity in patients with secondary syphi-lis.Methods:Double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the content of IFN-γin the sera of pa-tients with secondary syphilis and those with negative rapid plasma regain (RPR) as well as positive RPR after two years of treatment.The levels of IFN-γwere analyzed and compared in the three groups.Results:Serum levels of IFN-γsecondary syphilis patients with lesions of skin were sig-nificantly higher than those of normal controls and patients with negative RPR,with significant statistical difference(P<0.01).Lower serum levels of IFN-γwere seen in those with positive RPR as compared with negative RPR group and normal controls.The difference was significant ( P < 0.01).Conclusion:Cellular immunity tends to be boosted in patients of secondary syphilis with skin lesions,yet suppressed in those whose RPR remained positive.The cellular immune function may recover to normal state in patients with negative RPR after antibiotic intervention .
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