基于体素的多系统萎缩梯度回波横向弛豫率R2*分析

摘要

目的 对震颤麻痹型多系统萎缩(MSA-P)患者与正常人的梯度回波横向弛豫率R2*进行基于体素的分析,探索其全脑R2*情况的差异.方法 入组27例MSA-P患者及24例健康志愿者,分别行全脑结构成像及多回波梯度回波成像,然后对其R2*图进行基于体素的分析.结果 与对照组相比,MSA-P组R2*值减低累及双侧脑干、小脑半球、岛叶、颞叶、尾状核及胼胝体,差异具有统计学意义(P ＜0.005).结论 R2*可以反映MSA-P患者脑内变化,梯度回波序列在提高灵敏度的同时,也带来了较强的伪影,干扰了其检出效能.%Objective To explore the transverse relaxation rate with gradient echo R2 * changes in patients with Parkinsonian variant of multiple system atrophy ( MSA-P) with a voxel-based analysis of R2 * map. Methods Whole brain structural images and multi-echo T2 * weighted image were acquired in 27 patients with probable MSA-P and 24 healthy individuals. R2 * maps of the MSA-P were compared with the controls by voxel-based methods. Result Compared with the controls, MSA-P patients showed significant R2 * decrease bilaterally in brain stem, cerebellar hemispheres, insular lobe, temporal lobes, caudate nucleus, and corpus callosum ( P < 0. 005 ) . Conclusions R2 can reveal the significant brain involvements of MSA-P. The introduction of gradient echo may increase the sensitivity, although the susceptible artifact may interfere the detection efficiency of R2 *.