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Synaptic Dysfunction Mediated by Mutant LRRK2 in Parkinson's Disease Pathogenesis

机译：突变LRRK2介导的突触功能障碍在帕金森氏病发病机理中的作用

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作者
Nguyen, Maria Bac Ai.;
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作者单位

Northwestern University.;

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授予单位 Northwestern University.;
学科
学位 Ph.D.
年度 2019
页码 106 p.
总页数 106
原文格式 PDF
正文语种 eng
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专利

1. Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons [J] . Pan Ping-Yue, Li Xianting, Wang Jing, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2017,第47期

机译：Parkinson的病情相关的LRRK2过度活性激酶突变体破坏了腹部中脑神经元的突触囊泡
2. Age-dependent accumulation of oligomeric SNCA/a-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA) [J] . Philip Wing-Lok Ho, Chi-Ting Leung, Huifang Liu, Autophagy . 2020,第2期

机译：来自帕金森病的突变体LRRK2敲低小鼠模型中受损降解损伤的年龄依赖性寡聚蛋白：伴侣介导的自噬的治疗活化作用（CMA）
3. Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease. [J] . Jana S, Sinha M, Chanda D, Biochimica et biophysica acta. Molecular basis of disease: BBA . 2011,第6期

机译：多巴胺醌氧化产物介导的线粒体功能障碍：对多巴胺细胞毒性和帕金森氏病发病机制的影响。
4. Biochemical basis of activation of the Parkinson's disease-causative Leueihe-Rich Repeat Kinase 2 (LRRK2) by the disease-associated G2019S mutation [C] . Heung-Chin Cheng, Ryan Mills, Tim Johnson Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：疾病相关的G2019S突变激活帕金森疾病疾病疾病患者致病性乳酪肝致致残的重复激酶2（LRRK2）的生化基础
5. Parkinson’s Disease-Linked LRRK2 Structure and Model for Microtubule Interaction [D] . Deniston, Colin. 2020

机译：帕金森病的疾病联系LRRK2结构和微管互动模型
6. Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease [O] . Giulia Lamonaca, Mattia Volta 2020

机译：突触自噬中的α-突触核蛋白和LRRK2：帕金森氏病的早期功能障碍与晚期病理联系起来。
7. From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2 [O] . Andrea Mancini, Petra Mazzocchetti, Miriam Sciaccaluga, 2020

机译：从突触功能障碍到遗传帕金森病中的神经保护策略：LRRK2的课程

Synaptic Dysfunction Mediated by Mutant LRRK2 in Parkinson's Disease Pathogenesis

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