Objectives. Endometrial carcinoma is the most common gynecological malignancy in the United States, with over 42,000 cases diagnosed in 2009. While obese women with EC have been shown to have increased mortality due to both endometrial carcinoma and obesity-associated co-morbidities, some studies have reported improved survival. We conducted a retrospective cohort study of 222 women with primary endometrial cancer to examine the relationship between BMI and survival outcomes.Methods. Eligible women, aged 27-87 years, diagnosed from 1988 to 2007 with endometrial cancer at the University of California, Irvine Medical Center, were identified from the tumor registry. Data on demographic and clinical-pathological factors were collected from medical charts. Kaplan-Meier life table and Cox proportional hazards regression models were used for survival analysis.Results. Of the 222 patients included in the analysis, the majority had grade 1 tumors, type I histology, and stage 1 disease. Mean BMI was 32+/-11. 47% of patients were obese, with BMI .30. In univariate models, BMI was not significantly associated with overall survival or disease-free survival, with hazard ratios of 0.965 and 0.973 respectively. However, BMI was significantly associated with lower tumor grade, type I histology, no chemotherapy treatment, younger age at diagnosis and diabetes mellitus. Tumor grade, stage, histology, chemotherapy, radiation therapy, and age at diagnosis were all significantly associated with overall survival as well as disease recurrence.Conclusions. In our study, increased BMI at endometrial cancer diagnosis is not significantly associated with survival outcomes. This may reflect the combined effects of greater obesity-associated co-morbidities being offset by less aggressive histology or low-grade tumors in obese women with endometrial cancer.
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